abstract：BACKGROUND:In patients with coronary artery disease (CAD), low diastolic blood pressure (DBP) is associated with increased risk of myocardial infarction, but its association with angina is unknown. OBJECTIVES:The goal of this study was to examine the association of low DBP and angina in patients with CAD. METHODS:The...

journal_title：Journal of the American College of Cardiology

authors： Peri-Okonny PA,Patel KK,Jones PG,Breeding T,Gosch KL,Spertus JA,Arnold SV

更新日期：2018-09-11 00:00:00

abstract：BACKGROUND:Personalized external aortic root support (PEARS) was introduced in 2004 for prevention of aortic root dilatation in Marfan patients. The individual's aortic root is replicated by 3-dimensional printing. A polymer mesh sleeve is manufactured, which is implanted with the aim to support and stabilize the aorti...

journal_title：Journal of the American College of Cardiology

authors： Izgi C,Newsome S,Alpendurada F,Nyktari E,Boutsikou M,Pepper J,Treasure T,Mohiaddin R

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:Reperfusion therapy led to an important decline in mortality after ST-segment elevation myocardial infarction (STEMI). Because the rate of cardiogenic shock has not changed dramatically, the authors speculated that a reduction in the incidence or fatality rate of mechanical complications (MCs), the second ca...

journal_title：Journal of the American College of Cardiology

authors： Puerto E,Viana-Tejedor A,Martínez-Sellés M,Domínguez-Pérez L,Moreno G,Martín-Asenjo R,Bueno H

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:In the months after acute myocardial infarction (MI), risk for acute atherothrombotic events in nonculprit arteries increases several fold. OBJECTIVES:This study investigated whether sustained proinflammatory and prothrombotic endothelial alterations occur in remote vessels after MI. METHODS:Wild-type mice...

journal_title：Journal of the American College of Cardiology

authors： Moccetti F,Brown E,Xie A,Packwood W,Qi Y,Ruggeri Z,Shentu W,Chen J,López JA,Lindner JR

更新日期：2018-08-28 00:00:00

abstract：BACKGROUND:Recent studies reported left ventricular (LV) fibrosis in patients with primary mitral regurgitation (MR) thought to be principally due to mitral valve prolapse (MVP). OBJECTIVES:This study sought to evaluate the prevalence, characteristics, and prognostic implications of LV fibrosis in a large cohort of pr...

journal_title：Journal of the American College of Cardiology

authors： Kitkungvan D,Nabi F,Kim RJ,Bonow RO,Khan MA,Xu J,Little SH,Quinones MA,Lawrie GM,Zoghbi WA,Shah DJ

更新日期：2018-08-21 00:00:00

abstract：BACKGROUND:Left atrium (LA) physiology is influenced by changes in left ventricular (LV) performance and load. OBJECTIVES:The purpose of this study was to define the effect of acute changes in LV loading conditions on LA physiology in subacute myocardial infarction (MI). METHODS:MI was percutaneously induced in 19 Yo...

journal_title：Journal of the American College of Cardiology

authors： Ishikawa K,Watanabe S,Lee P,Akar FG,Lee A,Bikou O,Fish K,Kho C,Hajjar RJ

更新日期：2018-08-14 00:00:00

abstract：:Myocardial injury induces significant changes in ventricular structure and function at both the cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure. Unloading left ventricular pressure has been studied in both the short-term and long-term settings, as a means of preventing or re...

journal_title：Journal of the American College of Cardiology

authors： Uriel N,Sayer G,Annamalai S,Kapur NK,Burkhoff D

更新日期：2018-07-31 00:00:00

abstract：:Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year follow-up), CAC scoring has emerged as a widely available, consistent, and reproducible ...

journal_title：Journal of the American College of Cardiology

authors： Greenland P,Blaha MJ,Budoff MJ,Erbel R,Watson KE

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:Guidelines strongly recommend patients with heart failure with reduced ejection fraction (HFrEF) be treated with multiple medications proven to improve clinical outcomes, as tolerated. The degree to which gaps in medication use and dosing persist in contemporary outpatient practice is unclear. OBJECTIVES:Th...

journal_title：Journal of the American College of Cardiology

authors： Greene SJ,Butler J,Albert NM,DeVore AD,Sharma PP,Duffy CI,Hill CL,McCague K,Mi X,Patterson JH,Spertus JA,Thomas L,Williams FB,Hernandez AF,Fonarow GC

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:Women with atrial fibrillation are at a higher risk of stroke, despite treatment with warfarin. It is unclear if women treated with direct oral anticoagulants (DOACs) have better clinical outcomes, especially when considering the quality of anticoagulation control of warfarin. OBJECTIVES:This study compared...

journal_title：Journal of the American College of Cardiology

authors： Law SWY,Lau WCY,Wong ICK,Lip GYH,Mok MT,Siu CW,Chan EW

更新日期：2018-07-17 00:00:00

abstract：BACKGROUND:Intravascular volume expansion plays a major role in the prevention of contrast-induced acute kidney injury (CI-AKI). Recommended standard amounts of fluid infusion before procedures do not produce homogeneous responses in subjects with different initial hydration status. OBJECTIVES:The goal of this study w...

journal_title：Journal of the American College of Cardiology

authors： Maioli M,Toso A,Leoncini M,Musilli N,Grippo G,Ronco C,McCullough PA,Bellandi F

更新日期：2018-06-26 00:00:00

abstract：BACKGROUND:Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. OBJECTIVES:This study sought to describe the frequency, pathology...

journal_title：Journal of the American College of Cardiology

authors： Chin AS,Willemink MJ,Kino A,Hinostroza V,Sailer AM,Fischbein MP,Mitchell RS,Berry GJ,Miller DC,Fleischmann D

更新日期：2018-06-19 00:00:00

abstract：:The growing recognition that "health" takes place outside of the hospital and clinic, plus recent advances in mobile and wearable devices, have propelled the field of mobile health (mHealth). Cardiovascular disease and prevention are major opportunities for mHealth, as mobile devices can monitor key physiological sign...

journal_title：Journal of the American College of Cardiology

authors： McConnell MV,Turakhia MP,Harrington RA,King AC,Ashley EA

更新日期：2018-06-12 00:00:00

abstract：:The authors identified individual randomized controlled trials from previous meta-analyses and additional searches, and then performed meta-analyses on cardiovascular disease outcomes and all-cause mortality. The authors assessed publications from 2012, both before and including the U.S. Preventive Service Task Force ...

journal_title：Journal of the American College of Cardiology

authors： Jenkins DJA,Spence JD,Giovannucci EL,Kim YI,Josse R,Vieth R,Blanco Mejia S,Viguiliouk E,Nishi S,Sahye-Pudaruth S,Paquette M,Patel D,Mitchell S,Kavanagh M,Tsirakis T,Bachiri L,Maran A,Umatheva N,McKay T,Trinidad G,

更新日期：2018-06-05 00:00:00

abstract：BACKGROUND:Subclinical inflammation mediated in part by interleukin (IL)-1β participates in peripheral insulin resistance and impaired pancreatic insulin secretion. OBJECTIVES:The authors tested the hypothesis that the IL-1β inhibitor canakinumab reduces incident diabetes. METHODS:The authors randomized 10,061 patien...

journal_title：Journal of the American College of Cardiology

authors： Everett BM,Donath MY,Pradhan AD,Thuren T,Pais P,Nicolau JC,Glynn RJ,Libby P,Ridker PM

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:In the ISAR-CABG (Is Drug-Eluting-Stenting Associated with Improved Results in Coronary Artery Bypass Grafts?) trial, clinical outcomes at 1 year in patients undergoing treatment of saphenous vein graft lesions were superior with drug-eluting stents (DES) versus bare-metal stents. OBJECTIVES:The authors com...

journal_title：Journal of the American College of Cardiology

authors： Colleran R,Kufner S,Mehilli J,Rosenbeiger C,Schüpke S,Hoppmann P,Joner M,Mankerious N,Fusaro M,Cassese S,Abdel-Wahab M,Neumann FJ,Richardt G,Ibrahim T,Schunkert H,Laugwitz KL,Kastrati A,Byrne RA,ISAR-CABG Investigator

更新日期：2018-05-08 00:00:00

abstract：BACKGROUND:The current U.S. priority ranking for heart candidates is based on treatment intensity, not objective markers of severity of illness. This system may encourage centers to overtreat candidates. OBJECTIVES:This study sought to describe national variation in the intensity of treatment of adult heart transplant...

journal_title：Journal of the American College of Cardiology

authors： Parker WF,Anderson AS,Hedeker D,Huang ES,Garrity ER Jr,Siegler M,Churpek MM

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Myocarditis is an uncommon, but potentially fatal, toxicity of immune checkpoint inhibitors (ICI). Myocarditis after ICI has not been well characterized. OBJECTIVES:The authors sought to understand the presentation and clinical course of ICI-associated myocarditis. METHODS:After observation of sporadic ICI...

journal_title：Journal of the American College of Cardiology

authors： Mahmood SS,Fradley MG,Cohen JV,Nohria A,Reynolds KL,Heinzerling LM,Sullivan RJ,Damrongwatanasuk R,Chen CL,Gupta D,Kirchberger MC,Awadalla M,Hassan MZO,Moslehi JJ,Shah SP,Ganatra S,Thavendiranathan P,Lawrence DP,Groark

更新日期：2018-04-24 00:00:00

abstract：:Hypertension accounts for 1 in 5 deaths among American women, posing a greater burden for women than men, and is among their most important risk factors for death and development of cardiovascular and other diseases. Hypertension affects women in all phases of life, with specific characteristics relating to risk facto...

journal_title：Journal of the American College of Cardiology

authors： Wenger NK,Arnold A,Bairey Merz CN,Cooper-DeHoff RM,Ferdinand KC,Fleg JL,Gulati M,Isiadinso I,Itchhaporia D,Light-McGroary K,Lindley KJ,Mieres JH,Rosser ML,Saade GR,Walsh MN,Pepine CJ

更新日期：2018-04-24 00:00:00

abstract：:Recent progress and evolution in device engineering, surgical implantation practices, and periprocedural management have advanced the promise of durable support with left ventricular assist systems (LVAS) in patients with stage D heart failure. With greater uptake of LVAS globally, a growing population of LVAS recipie...

journal_title：Journal of the American College of Cardiology

authors： Berg DD,Vaduganathan M,Upadhyay GA,Singh JP,Mehra MR,Stewart GC

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Experimental and clinical studies show that prematurity leads to altered left ventricular (LV) structure and function with preserved resting LV ejection fraction (EF). Large-scale epidemiological data now links prematurity to increased early heart failure risk. OBJECTIVES:The authors performed echocardiogra...

journal_title：Journal of the American College of Cardiology

authors： Huckstep OJ,Williamson W,Telles F,Burchert H,Bertagnolli M,Herdman C,Arnold L,Smillie R,Mohamed A,Boardman H,McCormick K,Neubauer S,Leeson P,Lewandowski AJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:Patients with gout are at an increased risk of cardiovascular (CV) disease including myocardial infarction (MI), stroke, and heart failure (HF). OBJECTIVES:The authors conducted a cohort study to examine comparative CV safety of the 2 gout treatments-probenecid and allopurinol-in patients with gout. METHOD...

journal_title：Journal of the American College of Cardiology

authors： Kim SC,Neogi T,Kang EH,Liu J,Desai RJ,Zhang M,Solomon DH

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Long-term outcomes of Fontan patients who survive to age ≥16 years have not been well characterized. The Australian and New Zealand Fontan Registry (ANZFR) provides a unique opportunity to understand survival and complication rates in Fontan patients who transition to adult congenital heart disease centers. ...

journal_title：Journal of the American College of Cardiology

authors： Dennis M,Zannino D,du Plessis K,Bullock A,Disney PJS,Radford DJ,Hornung T,Grigg L,Cordina R,d'Udekem Y,Celermajer DS

更新日期：2018-03-06 00:00:00

abstract：BACKGROUND:Small studies have reported superiority of sirolimus (SRL) over calcineurin inhibitor (CNI) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). However, data on the long-term effect on CAV progression and clinical outcomes are lacking. OBJECTIVES:The aim of this study was to...

journal_title：Journal of the American College of Cardiology

authors： Asleh R,Briasoulis A,Kremers WK,Adigun R,Boilson BA,Pereira NL,Edwards BS,Clavell AL,Schirger JA,Rodeheffer RJ,Frantz RP,Joyce LD,Maltais S,Stulak JM,Daly RC,Tilford J,Choi WG,Lerman A,Kushwaha SS

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:In addition to scalability, human embryonic stem cells (hESCs) have the unique advantage of allowing their directed differentiation toward lineage-specific cells. OBJECTIVES:This study tested the feasibility of leveraging the properties of hESCs to generate clinical-grade cardiovascular progenitor cells and...

journal_title：Journal of the American College of Cardiology

authors： Menasché P,Vanneaux V,Hagège A,Bel A,Cholley B,Parouchev A,Cacciapuoti I,Al-Daccak R,Benhamouda N,Blons H,Agbulut O,Tosca L,Trouvin JH,Fabreguettes JR,Bellamy V,Charron D,Tartour E,Tachdjian G,Desnos M,Larghero J

更新日期：2018-01-30 00:00:00

abstract：BACKGROUND:Autosomal recessive hypercholesterolemia (ARH) is a rare lipid disorder characterized by premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data for clinical management and cardiovascular outcomes in ARH. OBJECTIVES:Evaluation of changes in lipid management, achievement of low-densit...

journal_title：Journal of the American College of Cardiology

authors： D'Erasmo L,Minicocci I,Nicolucci A,Pintus P,Roeters Van Lennep JE,Masana L,Mata P,Sánchez-Hernández RM,Prieto-Matos P,Real JT,Ascaso JF,Lafuente EE,Pocovi M,Fuentes FJ,Muntoni S,Bertolini S,Sirtori C,Calabresi L,Pavan

更新日期：2018-01-23 00:00:00

abstract：BACKGROUND:Several epidermal growth factor receptor (EGFR) inhibitors have been successfully developed for the treatment of cancer, limiting tumor growth and metastasis. EGFR is also expressed by leukocytes, but little is known about its role in the modulation of the immune response. OBJECTIVES:The aim of this study w...

journal_title：Journal of the American College of Cardiology

authors： Zeboudj L,Maître M,Guyonnet L,Laurans L,Joffre J,Lemarie J,Bourcier S,Nour-Eldine W,Guérin C,Friard J,Wakkach A,Fabre E,Tedgui A,Mallat Z,Tharaux PL,Ait-Oufella H

更新日期：2018-01-16 00:00:00

abstract：:Obesity continues to be among the top health concerns across the globe. Despite our failure to contain the high prevalence of obesity, we now have a better understanding of its pathophysiology, and how excess adiposity leads to type 2 diabetes, hypertension, and cardiovascular disease. Lifestyle modification is recomm...

journal_title：Journal of the American College of Cardiology

authors： Gadde KM,Martin CK,Berthoud HR,Heymsfield SB

更新日期：2018-01-02 00:00:00

abstract：BACKGROUND:Quantitative flow ratio (QFR) is a novel angiography-based method for deriving fractional flow reserve (FFR) without pressure wire or induction of hyperemia. The accuracy of QFR when assessed online in the catheterization laboratory has not been adequately examined to date. OBJECTIVES:The goal of this study...

journal_title：Journal of the American College of Cardiology

authors： Xu B,Tu S,Qiao S,Qu X,Chen Y,Yang J,Guo L,Sun Z,Li Z,Tian F,Fang W,Chen J,Li W,Guan C,Holm NR,Wijns W,Hu S

更新日期：2017-12-26 00:00:00

abstract：BACKGROUND:Life-threatening heparin-induced thrombocytopenia (HIT) is treated with the alternative nonheparin anticoagulants argatroban, lepirudin, or danaparoid. Frequently, the pentasaccharide fondaparinux is used off-label. OBJECTIVES:The authors sought to investigate the safety and efficacy of the different antico...

journal_title：Journal of the American College of Cardiology

authors： Schindewolf M,Steindl J,Beyer-Westendorf J,Schellong S,Dohmen PM,Brachmann J,Madlener K,Pötzsch B,Klamroth R,Hankowitz J,Banik N,Eberle S,Müller MM,Kropff S,Lindhoff-Last E

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:The combination of autologous mesenchymal stem cells (MSCs) and cardiac stem cells (CSCs) synergistically reduces scar size and improves cardiac function in ischemic cardiomyopathy. Whereas allogeneic (allo-)MSCs are immunoevasive, the capacity of CSCs to similarly elude the immune system remains controversi...

journal_title：Journal of the American College of Cardiology

authors： Natsumeda M,Florea V,Rieger AC,Tompkins BA,Banerjee MN,Golpanian S,Fritsch J,Landin AM,Kashikar ND,Karantalis V,Loescher VY,Hatzistergos KE,Bagno L,Sanina C,Mushtaq M,Rodriguez J,Rosado M,Wolf A,Collon K,Vincent L,

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds low-density lipoprotein receptor (LDLR), preventing its recycling. PCSK9 is a risk predictor and a biotarget in atherosclerosis progression. OBJECTIVES:The aim of this study was to determine whether the PCSK9-LDLR axis could predict risk in patient...

journal_title：Journal of the American College of Cardiology

authors： Bayes-Genis A,Núñez J,Zannad F,Ferreira JP,Anker SD,Cleland JG,Dickstein K,Filippatos G,Lang CC,Ng LL,Ponikowski P,Samani NJ,van Veldhuisen DJ,Zwinderman AH,Metra M,Lupón J,Voors AA

更新日期：2017-10-24 00:00:00

abstract：:Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remod...

journal_title：Journal of the American College of Cardiology

authors： Lavie CJ,Pandey A,Lau DH,Alpert MA,Sanders P

更新日期：2017-10-17 00:00:00

abstract：BACKGROUND:Genetic screening programs in unselected individuals with increased levels of low-density lipoprotein cholesterol (LDL-C) have shown modest results in identifying individuals with familial hypercholesterolemia (FH). OBJECTIVES:This study assessed the prevalence of genetically confirmed FH in patients with a...

journal_title：Journal of the American College of Cardiology

authors： Amor-Salamanca A,Castillo S,Gonzalez-Vioque E,Dominguez F,Quintana L,Lluís-Ganella C,Escudier JM,Ortega J,Lara-Pezzi E,Alonso-Pulpon L,Garcia-Pavia P

更新日期：2017-10-03 00:00:00

abstract：:Compared with traditional exercise tests, cardiopulmonary exercise testing (CPET) provides a thorough assessment of exercise integrative physiology involving the pulmonary, cardiovascular, muscular, and cellular oxidative systems. Due to the prognostic ability of key variables, CPET applications in cardiology have gro...

journal_title：Journal of the American College of Cardiology

authors： Guazzi M,Bandera F,Ozemek C,Systrom D,Arena R

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor blockers (ARB), beta-blockers and statins are recommended after acute myocardial infarction (AMI). Patients may adhere to some, but not all, therapies. OBJECTIVES:The authors investigated the effect of tradeoffs in adherence to ACE inhib...

journal_title：Journal of the American College of Cardiology

authors： Korhonen MJ,Robinson JG,Annis IE,Hickson RP,Bell JS,Hartikainen J,Fang G

更新日期：2017-09-26 00:00:00

abstract：BACKGROUND:Gasping is a natural reflex that enhances oxygenation and circulation during cardiopulmonary resuscitation (CPR). OBJECTIVES:This study sought to assess the relationship between gasping during out-of-hospital cardiac arrest and 1-year survival with favorable neurological outcomes. METHODS:The authors prosp...

journal_title：Journal of the American College of Cardiology

authors： Debaty G,Labarere J,Frascone RJ,Wayne MA,Swor RA,Mahoney BD,Domeier RM,Olinger ML,O'Neil BJ,Yannopoulos D,Aufderheide TP,Lurie KG

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Heart rate reduction as a therapeutic target has been investigated in adults with heart failure (HF). Ivabradine has shown promising efficacy, but has not been evaluated in children. Currently, treatment recommendations for chronic pediatric HF are based mainly on chronic HF guidelines for adults. OBJECTIVE...

journal_title：Journal of the American College of Cardiology

authors： Bonnet D,Berger F,Jokinen E,Kantor PF,Daubeney PEF

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:Limited data exist regarding transcatheter mitral valve replacement (TMVR) for patients with failed mitral valve replacement and repair. OBJECTIVES:This study sought to evaluate the outcomes of TMVR in patients with failed mitral bioprosthetic valves (valve-in-valve [ViV]) and annuloplasty rings (valve-in-r...

journal_title：Journal of the American College of Cardiology

authors： Yoon SH,Whisenant BK,Bleiziffer S,Delgado V,Schofer N,Eschenbach L,Fujita B,Sharma R,Ancona M,Yzeiraj E,Cannata S,Barker C,Davies JE,Frangieh AH,Deuschl F,Podlesnikar T,Asami M,Dhoble A,Chyou A,Masson JB,Wijeysund

更新日期：2017-08-29 00:00:00

abstract：:High-sensitivity cardiac troponin (hs-cTn) assays have been used clinically by thousands of physicians in many countries throughout the world since their clinical introduction 7 years ago. In the early diagnosis of myocardial infarction (MI), beyond doubt, the most important indication of hs-cTn assays, these simple, ...

journal_title：Journal of the American College of Cardiology

authors： Twerenbold R,Boeddinghaus J,Nestelberger T,Wildi K,Rubini Gimenez M,Badertscher P,Mueller C

更新日期：2017-08-22 00:00:00